Survodutide 10mg

Survodutide (also known as BI 456906) is a 29-amino acid synthetic peptide analog derived from the endogenous hormone glucagon, engineered with structural modifications from GLP-1 to confer potent dual agonism at both the glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR) . This analog incorporates a C18 diacid albumin-binding moiety at position 24, which prolongs its terminal half-life to approximately 44-140 hours in preclinical models, enabling sustained pharmacokinetic profiles suitable for once-weekly dosing regimens in investigational studies . In cellular assays, Survodutide demonstrates potent activation of human GLP-1R and GCGR, with reported EC50 values of 0.33 nM and 0.52 nM respectively in CHO-K1 cell lines .

The dual-action mechanism of Survodutide addresses energy homeostasis through two complementary pathways. GLP-1R agonism delays gastric emptying, promotes satiety, and suppresses caloric intake via activation of neuronal populations in circumventricular organs and hypothalamic nuclei . Simultaneously, GCGR agonism increases energy expenditure through direct hepatic effects, promoting lipid oxidation and enhancing overall negative energy balance . This coordinated approach has demonstrated superior body weight reduction in diet-induced obese murine models compared to selective GLP-1R mono-agonists like semaglutide .

Researchers are actively investigating Survodutide for its potential applications in metabolic disorders. Clinical studies have reported dose-dependent body weight reductions of up to 19% in Phase 2 trials, along with groundbreaking improvements in MASH resolution and liver fibrosis . Additionally, emerging preclinical evidence suggests Survodutide may exert positive inotropic effects in isolated human atrial preparations, warranting further exploration of its cardiovascular implications . This product is supplied as a high-purity (≥99%) lyophilized powder suitable for reconstitution in sterile buffers or solvents. It is strictly intended for laboratory research use only and is not approved for human or veterinary therapeutic administration. Store lyophilized powder at -20°C, protected from light and moisture