EPO 5000IU

Erythropoietin (EPO) 5000IU is a recombinant form of the endogenous cytokine hormone produced primarily by the kidneys in response to tissue hypoxia. This research-grade preparation consists of a 165-amino acid glycoprotein with a molecular weight of approximately 30.4 kDa, engineered to mimic the biological activity of native human EPO. When introduced into appropriate in vitro cell culture models containing erythroid progenitor cells (such as BFU-E and CFU-E), EPO binds specifically to the EPO receptor (EPOR), initiating the JAK2/STAT5 signaling cascade that prevents apoptosis and promotes terminal differentiation into mature erythrocytes.

This 5000IU vial provides a standardized, potent dose for consistent experimental replication in studies focused on oxygen sensing, angiogenesis, and hematological disorders. Beyond its classic role in red blood cell mass regulation, researchers are increasingly studying EPO for its pleiotropic, non-hematopoietic effects, including potential tissue-protective properties mediated by the heterodimeric receptor (EPOR/βcR) in cardiac, neural, and renal tissue models. This product is supplied as a sterile, lyophilized powder requiring reconstitution with bacteriostatic water or appropriate buffer. It is strictly for in vitro laboratory research use and is not for human or veterinary administration. Store lyophilized product at -20°C for long-term stability.