MOTS-c

MOTS-c 10mg – Premium Mitochondrial-Derived Peptide for Metabolic Health, Longevity & Exercise Mimetic Research | Advanced 16-Amino Acid Peptide to Enhance Insulin Sensitivity, Fat Oxidation & Mitochondrial Function Insights

Optimize cellular energy and metabolic performance with MOTS-c 10mg from Ion Peptide, the high-purity mitochondrial-derived peptide designed for advanced laboratory studies on metabolic regulation, insulin sensitivity, fat metabolism, and longevity pathways. As a unique 16-amino acid peptide encoded by the mitochondrial 12S rRNA gene, MOTS-c acts as a systemic signaling molecule that activates AMPK, improves glucose uptake, and enhances mitochondrial biogenesis — offering researchers a powerful tool for investigating age-related metabolic decline, obesity models, exercise-like benefits, and overall mitochondrial health without relying on traditional caloric restriction or intense physical activity.

Premium Product Overview

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is supplied as a stable lyophilized acetate salt in convenient 10mg vials for easy reconstitution.

With the sequence MRWQEMGYIFYPRKLR, molecular formula C₅₁H₈₄N₁₆O₁₂S₂ (free base), and molecular weight of approximately 2,174 Da, this short peptide translocates to the nucleus under metabolic stress to regulate gene expression related to metabolism. Manufactured at ≥99% purity (third-party HPLC & MS verified), MOTS-c 10mg provides researchers with a bioactive, mitochondria-specific tool for precise investigations into AMPK activation, PGC-1α upregulation, and systemic metabolic homeostasis.

Key Research Benefits of MOTS-c 10mg

• Enhanced Insulin Sensitivity & Glucose Regulation: Improves glucose uptake in skeletal muscle and reduces insulin resistance in metabolic dysfunction models.
• Fat Oxidation & Weight Management: Promotes fatty acid utilization, reduces fat accumulation (especially visceral fat), and supports lean body composition.
• Mitochondrial Biogenesis & Energy Efficiency: Activates AMPK and PGC-1α pathways to increase mitochondrial density and function for better cellular energy production.
• Exercise Mimetic Effects: Delivers many benefits of physical exercise, including improved endurance and metabolic flexibility, even in sedentary research models.
• Anti-Aging & Longevity Insights: Protects against age-related metabolic decline, oxidative stress, and inflammation while supporting healthy lifespan extension in preclinical studies.

Researchers frequently describe MOTS-c as the “mitochondrial metabolic regulator” or “exercise in a vial” peptide for its ability to coordinate whole-body energy balance from within the mitochondria.

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Quality Assurance & Usage in Research

Sourced exclusively for laboratory research with USA-verified COAs. MOTS-c 10mg reconstitutes easily with bacteriostatic water. Store lyophilized vials at -20°C and reconstituted solutions refrigerated.

Common Research Protocols (for reference only): Typical subcutaneous doses in studied models range from 5–15 mg per day or 5–10 mg 3–5 times per week. Some protocols explore daily administration for 4–12 weeks. Always follow precise reconstitution and institutional guidelines.

Important Research Considerations

MOTS-c 10mg is a potent research chemical intended strictly for laboratory use only. It has demonstrated excellent tolerability in preclinical and early clinical studies with minimal side effects. Common observations are very mild; transient injection site reactions may occur. It is not approved by regulatory agencies for human therapeutic, cosmetic, or performance use. Prioritize proper protocols, biomarker monitoring (insulin sensitivity markers, mitochondrial function, body composition), and consult qualified professionals for any application beyond strict lab research.